Certified Clinical Research Associate (CCRA) Practice Exam

The correct answer is adaptive design because this type of clinical trial allows for modifications to the trial parameters based on interim observations or data collected during the study. This adaptability can include changes to the sample size, treatment regimens, or even the randomization scheme itself, depending on how participants are responding to the treatment or other factors that may emerge. By allowing for such adjustments, adaptive designs aim to make trials more efficient and ethical, potentially accelerating the understanding of a treatment's efficacy and safety. This flexibility can lead to more informed decisions throughout the course of the trial, maximizing the chances of finding beneficial results while minimizing the exposure of participants to ineffective treatments. In contrast, other trial designs like randomized, parallel, and crossover designs typically follow a predetermined course without adjustments based on interim findings, which can limit their adaptability in response to real-world data that emerges during the study.